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Brief periods of inactivity reduce leg microvascular, but not macrovascular, function in healthy young men.

08:00 EDT 15th August 2018 | BioPortfolio

Summary of "Brief periods of inactivity reduce leg microvascular, but not macrovascular, function in healthy young men."

What is the central question of this study? We aimed to examine leg vascular responses to brief periods of inactivity. What is the main finding and its importance? We demonstrate that a mere 10 min of sitting is sufficient to impair leg microvascular function (reactive hyperaemia). However, conduit artery vasodilatation (flow-mediated dilatation) was unaffected, indicating maintained macrovascular function. Interestingly, immobile supine rest also resulted in a reduction in microvascular function alone that was prevented when calf muscle contractions were performed. Collectively, these data highlight the susceptibility of the microcirculation to short periods of inactivity and the beneficial role of skeletal muscle contraction for vascular health.

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This article was published in the following journal.

Name: Experimental physiology
ISSN: 1469-445X
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