Brief periods of inactivity reduce leg microvascular, but not macrovascular, function in healthy young men.

08:00 EDT 15th August 2018 | BioPortfolio

Summary of "Brief periods of inactivity reduce leg microvascular, but not macrovascular, function in healthy young men."

What is the central question of this study? We aimed to examine leg vascular responses to brief periods of inactivity. What is the main finding and its importance? We demonstrate that a mere 10 min of sitting is sufficient to impair leg microvascular function (reactive hyperaemia). However, conduit artery vasodilatation (flow-mediated dilatation) was unaffected, indicating maintained macrovascular function. Interestingly, immobile supine rest also resulted in a reduction in microvascular function alone that was prevented when calf muscle contractions were performed. Collectively, these data highlight the susceptibility of the microcirculation to short periods of inactivity and the beneficial role of skeletal muscle contraction for vascular health.


Journal Details

This article was published in the following journal.

Name: Experimental physiology
ISSN: 1469-445X


DeepDyve research library

PubMed Articles [17170 Associated PubMed Articles listed on BioPortfolio]

The interrelation of endothelial function and microvascular reactivity in different vascular beds, and risk assessment in hypertension: results from the Doxazosin-ramipril study.

There are several non-invasive methods to study endothelial function, but their interrelation and association to cardiovascular risk have not been well evaluated. We studied macrovascular and microvas...

Reliability of microvascular responsiveness measures derived from near-infrared spectroscopy across a variety of ischemic periods in young and older individuals.

Cardiovascular disease (CVD) is associated with impairments in microvascular responsiveness. Therefore, reliably assessing microvascular function is clinically relevant. Thus, this study aimed to exam...

Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents.

Microvascular endothelial dysfunction, which is at the early stage of atherosclerosis, precedes macrovascular endothelial dysfunction. The study is aimed to investigate the mechanism underlying the im...

Increased vascular function and superoxide dismutase activity in physically active vs. inactive adults living with HIV.

This study compared macro- and microvascular endothelial function and redox status in active vs. inactive HIV-infected patients (HIVP) under antiretroviral therapy. Using a cross-sectional design, mac...

Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects.

Prolonged skeletal muscle inactivity (e.g. limb immobilization, bed rest, mechanical ventilation, spinal cord injury, etc.) results in muscle atrophy that manifests into a decreased quality of life an...

Clinical Trials [11757 Associated Clinical Trials listed on BioPortfolio]

Diet Composition and Physical Inactivity on Insulin Sensitivity and β-cell Function

Physical inactivity results in reductions in glucose tolerance and less sensitivity to insulin. If this inactivity lasts long enough it can result in insulin resistance and type 2 diabetes...

Effect of Empagliflozin on Macrovascular and Microvascular Circulation and on Endothelium Function

Empagliflozin may lead to improved vascular and endothelial function in the macro- (pulse wave reflection) and microcirculation (retinal circulation) and improve cardiovascular risk factor...

Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry

Long-term prognostic value of macrovascular and microvascular coronary artery stenoses in each type of cardiomyopathy.

Anabolic Resistance

This is an interventional study enrolling older individuals aged 60-85y to observe changes during physical inactivity. This study is investigating the relation between short-term physical ...

Prevalence of Macrovascular Disease in Type 2 Diabetes Mellitus

The study aim is to establish a consecutive population of newly referred type 2 diabetes mellitus patients and among these to describe the degree of macrovascular disease by evaluating lef...

Medical and Biotech [MESH] Definitions

Healthy People Programs are a set of health objectives to be used by governments, communities, professional organizations, and others to help develop programs to improve health. It builds on initiatives pursued over the past two decades beginning with the 1979 Surgeon General's Report, Healthy People, Healthy People 2000: National Health Promotion and Disease Prevention Objectives, and Healthy People 2010. These established national health objectives and served as the basis for the development of state and community plans. These are administered by the Office of Disease Prevention and Health Promotion (ODPHP). Similar programs are conducted by other national governments.

The development and maintenance of optimal physical, mental, spiritual, and social well-being and function with advancing age.

An affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.

The systematic checking of the condition and function of a patient's CENTRAL NERVOUS SYSTEM during disease periods or following injuries, using various NEUROLOGICAL DIAGNOSTIC TECHNIQUES.

The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.

Quick Search


DeepDyve research library

Relevant Topics

Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...

Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Searches Linking to this Article