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Metabolic syndrome is a critically important precursor to the onset of many diseases, such as cardiovascular disease, and cardiovascular disease is the leading cause of death worldwide. The primary risk factors of metabolic syndrome include hyperglycemia, abdominal obesity, dyslipidemia, and high blood pressure. It has been well documented that metabolic syndrome alters vascular endothelial and smooth muscle cell functions in the heart, brain, kidney, and peripheral vessels. However, there is less information regarding how metabolic syndrome can affect pulmonary vascular function and ultimately increase an individual's risk of developing pulmonary vascular diseases, such as pulmonary hypertension. We here review in detail how metabolic syndrome affects pulmonary vascular function. Graph abstract: XXXX This article is protected by copyright. All rights reserved.
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Name: The Journal of physiology
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