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Beta-cypermethrin exposure affects female reproduction by enhancing oxidative stress in mice uterine tissue.

08:00 EDT 20th August 2018 | BioPortfolio

Summary of "Beta-cypermethrin exposure affects female reproduction by enhancing oxidative stress in mice uterine tissue."

This study aimed to investigate the toxicity mechanism of beta-cypermethrin (beta-CYP) on fertility in female mice. Eighty female mice were randomly assigned to four groups of 20 mice each: one control group and three beta-CYP-treated groups. The control group was administered corn oil only, while the three beta-CYP-treated groups were given corn oil containing 1.38, 2.76, and 5.52 mg/kg bw.d beta-CYP for 180 days through intragastric administration. The results found that the 2.76 and 5.52 mg/kg bw.d beta-CYP significantly decreased the rate of successful pregnancy (p < 0.05). The concentrations of biomarkers related to oxidative stress were significantly elevated, while the concentrations of the endogenic enzymatic antioxidants were significantly decreased by the beta-CYP exposure (all p < 0.05). The expression levels of inflammatory-related molecules and the DNA-protein crosslink coefficient in mice uteri were significantly increased after beta-CYP exposure (all p < 0.05). The concentration of 8-hydroxy-2-deoxyguanosine was significantly increased in the 5.52 mg/kg bw.d beta-CYP group (p < 0.05). These results suggested that beta-CYP exposure significantly decreased female reproduction by enhancing oxidative stress in uterine tissue, which led to the increased inflammatory response and oxidative DNA damage in uterine tissue.

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Name: Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
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Medical and Biotech [MESH] Definitions

Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.

Animals and plants which have, as their normal mode of reproduction, both male and female sex organs in the same individual.

In animals, the social relationship established between a male and female for reproduction. It may include raising of young.

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Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).

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