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The relationship between muscle mass and function in cancer cachexia: smoke and mirrors?

08:00 EDT 22nd August 2018 | BioPortfolio

Summary of "The relationship between muscle mass and function in cancer cachexia: smoke and mirrors?"

Randomized clinical trials of cancer cachexia interventions are based on the premise that an increase in the muscle mass of patients is associated with consequent improvements in muscle function, and ultimately, quality of life. However, recent trials that have succeeded in demonstrating increases in lean body mass have been unable to show associated increases in patient physical function. In this review, we examine the potential causes for this lack of association between muscle mass and function in cancer cachexia, paying particular attention to those factors that may be at play when using body composition analysis techniques involving cross-sectional imaging. Moreover, we propose a new population-specific model for the relationship between muscle mass and physical function in patients with cancer cachexia.

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This article was published in the following journal.

Name: Current opinion in supportive and palliative care
ISSN: 1751-4266
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Medical and Biotech [MESH] Definitions

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