Advertisement

Topics

How cellular Zn signaling drives physiological functions.

08:00 EDT 18th August 2018 | BioPortfolio

Summary of "How cellular Zn signaling drives physiological functions."

Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn homeostasis is critical for cell function and survival. Zn, acting as a first or second messenger, triggers signaling pathways that mediate the physiological roles of Zn. Transient changes in Zn concentrations within the cell or in the extracellular region occur following its release from Zn binding metallothioneins, its transport across membranes by the ZnT or ZIP transporters, or release of vesicular Zn. These transients activate a distinct Zn sensing receptor, ZnR/GPR39, or modulate numerous proteins and signaling pathways. Importantly, Zn signaling regulates cellular physiological functions such as: proliferation, differentiation, ion transport and secretion. Indeed, novel therapeutic approaches aimed to maintain Zn homeostasis and signaling are evolving. This review focuses on recent findings describing roles of Zn and its transporters in regulating physiological or pathological processes.

Affiliation

Journal Details

This article was published in the following journal.

Name: Cell calcium
ISSN: 1532-1991
Pages: 53-63

Links

DeepDyve research library

PubMed Articles [16850 Associated PubMed Articles listed on BioPortfolio]

Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+/Calpain Pathway.

The Wnt signaling pathway has essential functions in the central nervous system, where it regulates the major physiological functions of neurons, including development, differentiation, and plasticity...

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.

Cilia are organelles specialized in movement and signal transduction. The ciliary transient receptor potential ion channel polycystin-2 (TRPP2) controls elementary cilia-mediated physiological functio...

It's all about tau.

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to bind and stabilize microtubules. However, it is now becoming evident that the functions of tau extend b...

Mitochondrial Ca signaling.

Mitochondrial Ca regulation is crucial for bioenergetics and cellular signaling. The mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled with the discovery of mitocho...

Short-term gain, long-term pain: the senescence life cycle and cancer.

Originally thought of as a stress response end point, the view of cellular senescence has since evolved into one encompassing a wide range of physiological and pathological functions, including both p...

Clinical Trials [3184 Associated Clinical Trials listed on BioPortfolio]

Desipramine for Improving Cellular Signaling and Decreasing Symptoms of Major Depression

This study will determine the effectiveness of desipramine in improving cellular signaling, and thereby decreasing symptoms of depression in people with major depressive disorder (MDD).

Specialized Food Plan Based on Individual Physiological Comprehensive Body Assessments Accompanied With Cellular Repair Therapy to Decrease Inflammation Cognitively Impaired Patients

Diet plays a large role in inflammation, oxidative stress and cognition; however, every person's body type, resting metabolic rate, BMI, and inflammation levels vary. Through performing ph...

GLP-1 Signaling in Truncally Vagotomized Subjects

Investigation of the importance of vagal signaling for the glucohomeostatic effects of GLP-1. The study will include physiological studies of truncally vagotomized participants and matched...

Effects of Augmented Reality on Humans

Nowadays, augmented reality (AR) has gained attention but little is known concerning its repercussion in individuals when considering some mental and physiological aspects. Therefore, the ...

Pioglitazone Therapy of Autoimmune Pulmonary Alveolar Proteinosis Autoimmune Pulmonary Alveolar Proteinosis

Pulmonary alveolar proteinosis (PAP) is a syndrome of surfactant accumulation, respiratory failure, and innate immune deficiency for which therapy remains limited to whole lung lavage (WLL...

Medical and Biotech [MESH] Definitions

Cellular functions, mechanisms, and activities.

Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.

A family of nucleotide diphosphate kinases that play a role in a variety of cellular signaling pathways that effect CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS. They are considered multifunctional proteins that interact with a variety of cellular proteins and have functions that are unrelated to their enzyme activity.

The functions and activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life.

Physiological functions characteristic of plants.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Searches Linking to this Article