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Ovarian neuroendocrine carcinoma of metastatic origin: clues for diagnosis.

08:00 EDT 29th August 2018 | BioPortfolio

Summary of "Ovarian neuroendocrine carcinoma of metastatic origin: clues for diagnosis."

Neuroendocrine tumors of the ovary are rare and of uncertain histogenesis. They may be primary or metastatic. Pathogenesis of ovarian carcinomas remains unknown. We report the case of an ovarian large cell carcinoma expressing all neuroendocrine markers (CD56, Chromogranin A, Synaptophysin) that presented as a primary tumor and coexisted with a typical endometrial serous carcinoma also expressing one neuroendocrine marker (CD56). The two tumors had identical molecular mutational profiles, as examined by Next Generation Sequencing. We propose that the ovarian neuroendocrine tumor was metastatic from an endometrial serous carcinoma with limited neuroendocrine differentiation.

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Name: Human pathology
ISSN: 1532-8392
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Medical and Biotech [MESH] Definitions

A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)

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