Efficacy of cloxacillin versus cefazolin for methicillin-susceptible bacteraemia (CloCeBa): study protocol for a randomised, controlled, non-inferiority trial.

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Summary of "Efficacy of cloxacillin versus cefazolin for methicillin-susceptible bacteraemia (CloCeBa): study protocol for a randomised, controlled, non-inferiority trial."

Methicillin-susceptible (MSSA) bacteraemia is a common and severe disease responsible for approximately 65 000 deaths every year in Europe. Intravenous antistaphylococcal penicillins (ASP) such as cloxacillin are the current recommended antibiotics. However, increasing reports of toxicity and recurrent stock-outs of ASP prompted healthcare providers to seek for alternative antibiotic treatment. Based on retrospective studies, cefazolin, a first-generation cephalosporin, is recommended in patients at risk of severe ASP-associated toxicity.We hypothesised that cefazolin has a non-inferior efficacy in comparison to cloxacillin, with a better safety profile for the treatment of MSSA bacteraemia.


Journal Details

This article was published in the following journal.

Name: BMJ open
ISSN: 2044-6055
Pages: e023151


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Medical and Biotech [MESH] Definitions

A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.

One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.

Antibiotic analog of CLOXACILLIN.

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.

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