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Combinations of novel pulse-echo acquisitions and clutter filtering techniques can improve the sensitivity and specificity of power Doppler images, thus reducing the need for exogenous contrast enhancement. We acquire echoes following bursts of Doppler pulse transmissions sparsely applied in regular patterns over long durations. The goal is to increase the sensitivity of the acquisition to slow disorganized patterns of motion from peripheral blood perfusion. To counter a concomitant increase in clutter signal power, we arrange the temporal echo acquisitions into two data-array axes, combine them with a spatial axis for the tissue region of interest, and apply 3-D singular-value decomposition (SVD) clutter filtering. Successful separation of blood echoes from other echo-signal sources requires that we partition the 3-D-SVD core tensor. Unfortunately, the clutter and blood subspaces do not completely uncouple in all situations, so we developed a statistical classifier that identifies the core-tensor subspace dominated by tissue-clutter power. This paper describes an approach to subspace partitioning as required for optimizing power-Doppler imaging of peripheral perfusion. The technique is validated using echo simulation, flow-phantom data, and in vivo data from a murine melanoma model. We find that for narrow-eigen-bandwidth clutter signals, we can routinely map phantom flows and tumor perfusion signals at speeds less than 3 ml/min. The proposed method is well suited to peripheral perfusion imaging applications.
This article was published in the following journal.
Name: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
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Descriptive anatomy based on three-dimensional imaging (IMAGING, THREE-DIMENSIONAL) of the body, organs, and structures using a series of computer multiplane sections, displayed by transverse, coronal, and sagittal analyses. It is essential to accurate interpretation by the radiologist of such techniques as ultrasonic diagnosis, MAGNETIC RESONANCE IMAGING, and computed tomography (TOMOGRAPHY, X-RAY COMPUTED). (From Lane & Sharfaei, Modern Sectional Anatomy, 1992, Preface)
Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.
Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
Alliances Astrazeneca Bioethics Boehringer Clinical Research Organization Collaborations GSK Johnson & Johnson Lilly Merck Mergers and Acquisitions Nexium Novartis Pfizer Roche Sanofi ...
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