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Intravenous Ketamine as an adjunct to procedural sedation during burn wound care and dressing changes.

08:00 EDT 5th September 2018 | BioPortfolio

Summary of "Intravenous Ketamine as an adjunct to procedural sedation during burn wound care and dressing changes."

Little has been published regarding intravenous (IV) ketamine for burn wound care in adult patients. Ketamine may serve as a safe alternative to provide conscious sedation and limit opioid administration to patients. The purpose of this study was to characterize IV ketamine use during burn wound care and establish its potential role as a safe adjunct to opioid and benzodiazepine medications. This is a retrospective review of adult patients admitted to a regional burn center who received IV ketamine for burn wound care. Patient demographics, medications, and ketamine-related side effects including hypertension and dysphoric reactions were recorded. Cardiopulmonary complications were also tracked. Thirty-six patients met inclusion criteria; 50 total cases were performed. The median patient age was 37 [IQR 28 - 55] years with a median burn size of 9.5 [IQR 4.0 - 52] %TBSA. The median ketamine dose administered was 1.2 [IQR 0.8 - 2.1] mg/kg. IV midazolam was administered in almost all cases (98%) at a median dose of 3.0 [IQR 2.0 - 5.0] mg. Opioids were administered in 13 of 50 cases (26%) at a median morphine equivalent dose of 10 [IQR 5.0 - 18] mg. In 46 cases (92%), patients denied unpleasant recall of medication. Dysphoric reactions were observed in 3 cases (6%). Ketamine-induced hypertension occurred in 3 cases (6%) and all immediately responded to IV labetalol. There were no cardiopulmonary complications. These findings suggest IV ketamine provides a safe analgesia and sedative option for burn wound care. Given these findings, IV ketamine for burn wound care warrants further study.

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Journal Details

This article was published in the following journal.

Name: Journal of burn care & research : official publication of the American Burn Association
ISSN: 1559-0488
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