Radioiodination and biological distribution of a new s-triazine derivative for tumor uptake evaluation.

08:00 EDT 7th September 2018 | BioPortfolio

Summary of "Radioiodination and biological distribution of a new s-triazine derivative for tumor uptake evaluation."

A newly synthesized s-triazine derivative 1,1',1"-(((1,3,5-triazine-2,4,6-triyl) tris (azanediyl)) tris (benzene-4,1-diyl))tris (ethan-1-one), (1), was synthesized as a part of an ongoing research for development of novel s-triazine based radiopharmaceuticals. In-vitro cell viability assay against different human cancer cell lines showed very promising inhibitory activity of the synthesized compound. This findings encouraged the radioiodination of 1 to study the degree of its localization in tumor site for evaluating the possibility of its use as a tumor imaging agent. The biodistribution study showed good localization of the radioiodinated derivative 2 at tumor site following i.v. administration in solid tumor bearing mice. Finally, in a trial to understand the mechanism of the anticancer effect exerted by 1, a target prediction study and a docking study were performed. The results of the first study showed that focal adhesion kinase is a possible target for compound 1 and the docking study confirmed successful binding of both compound 1 and its radioiodinated derivative 2 to the binding site of FAK. As a conclusion, the results of this study makes suggest that, compound 2 could be used as a potential agent for tumor imaging after preclinical trials.


Journal Details

This article was published in the following journal.

Name: Journal of labelled compounds & radiopharmaceuticals
ISSN: 1099-1344


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