Track topics on Twitter Track topics that are important to you
The incidence of cardiovascular disease (CVD) is lower in pre-menopausal women but increases with age and menopause compared to similar-aged men. Based on the prevalence of CVD in the post-menopausal women, sex hormone-dependent mechanisms have been postulated to be the primary factors responsible for the protection from CVD in pre-menopausal women. Recent Women's Health Initiative studies, Cochrane review, ELITE and KEEPS studies suggest that beneficial effects of hormone replacement therapy (HRT) are seen in women less than 60 years of age and if initiated in less than ten years of menopause. In contrast, the beneficial effects of HRT are not seen in women greater than 60 years of age and if commenced after ten years of menopause. The higher incidence of CVD and the failure of HRT in post-menopausal aged women could be partly associated with fundamental differences in the vascular structure and function between men and women and in between pre and post-menopausal women, respectively. In this regard, previous studies from human and animal studies identified several sex differences in the vascular function and the associated mechanisms. Female sex hormone 17βEstradiol (17βE) regulates the majority of these mechanisms. In this review, we summarize the sex differences in vascular structure, myogenic properties, endothelial-dependent and -independent mechanisms and the role of 17βE in the regulation of vascular function.
This article was published in the following journal.
Name: American journal of physiology. Heart and circulatory physiology
Diseases of the cardiovascular system are the leading cause of morbidity and mortality in men and women in developed countries, and CVD is becoming more prevalent in developing countries. Atherosclero...
Sex differences in cardiac fibrosis point to the regulatory role of 17β-Estradiol (E2) in cardiac fibroblasts (CF). We therefore asked whether male and female CF in rodent and human models are differ...
Diabetes-related vascular complication rates remain unacceptably high despite guideline-based medical therapies that are significantly more effective in individuals without diabetes. This critical gap...
The phenotype switching of vascular smooth muscle cells (VSMCs) plays a key role during development and progression of vascular remodeling diseases. Recent studies show that GLP-1 can inhibit intima t...
The present study examined how a gene related to functioning of the dopaminergic system, catechol-O-methyltransferase (COMT), and estradiol were related to brain functioning in healthy postmenopausal ...
This study is to identify the independent effect of estradiol (E2) on endothelin-1 (ET-1) mediated vasomotor function in women. This study is the first step in recognizing the impact of ov...
Recent large randomized, placebo-controlled studies assessing the health effects of HT question the overall benefits of long term HT, especially with respect to cardiovascular disease. How...
This study will define the relationship of cardiac, vascular function and skeletal muscle blood flow (individually and together) to cardiovascular exercise capacity in in men and women wit...
The purpose of this study is to evaluate potential mechanisms by which estradiol deficiency accelerates fat gain and abdominal fat accumulation in women.
Aging is the primary risk factor for Alzheimer's disease (AD), which is a rapidly growing public health concern. Understanding the mechanisms of normal brain aging may provide insight into...
Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
An LDL-receptor related protein that combines with cell surface FRIZZLED RECEPTORS to form WNT PROTEIN-binding receptors. The protein plays an important role in the WNT SIGNALING PATHWAY during EMBRYONIC DEVELOPMENT and in regulation of vascular cell proliferation.
Compounds which inhibit or antagonize the biosynthesis or action of estradiol.
Cytoplasmic proteins that bind estradiol, migrate to the nucleus, and regulate DNA transcription.
Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...
Cardiology is a specialty of internal medicine. Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...