Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish.

08:00 EDT 8th September 2018 | BioPortfolio

Summary of "Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish."

Spatio-temporal perturbation of signaling pathways in vivo remains challenging and requires precise transgenic control of signaling effectors. Fibroblast Growth Factor (FGF) signaling guides multiple developmental processes including body axis formation and cell fate patterning. In zebrafish, mutants and chemical perturbations affecting FGF signaling have uncovered key developmental processes; however, these approaches cause embryo-wide perturbations, rendering assessment of cell-autonomous versus non-autonomous requirements for FGF signaling in individual processes difficult.


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This article was published in the following journal.

Name: Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177


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