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Mebendazole potentiates radiation therapy in triple-negative breast cancer.

08:00 EDT 6th September 2018 | BioPortfolio

Summary of "Mebendazole potentiates radiation therapy in triple-negative breast cancer."

The lack of a molecular target in triple negative breast cancer (TNBC) makes it one of the most challenging breast cancers to treat. Radiation therapy (RT) is an important treatment modality for managing breast cancer, however we previously showed that RT can also reprogram a fraction of the surviving BC cells into BC initiating cells (BCICs), that are thought to contribute to disease recurrence. In this study we characterize mebendazole as a drug with potential for preventing radiation-induced reprogramming from occurring and improve the effect of RT in TNBC patients.

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This article was published in the following journal.

Name: International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Pages:

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