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This article presents our steps to integrate complex and partly unstructured medical data into a clinical research database with subsequent decision support. Our main application is an integrated faceted search tool, accompanied by the visualisation of results of automatic information extraction from textual documents. We describe the details of our technical architecture (open-source tools), to be replicated at other universities, research institutes, or hospitals. Our exemplary use cases are nephrology and mammography. The software was first developed in the nephrology domain and then adapted to the mammography use case. We report on these case studies, illustrating how the application can be used by a clinician and which questions can be answered. We show that our architecture and the employed software modules are suitable for both areas of application with a limited amount of adaptations. For example, in nephrology we try to answer questions about the temporal characteristics of event sequences to gain significant insight from the data for cohort selection. We present a versatile time-line tool that enables the user to explore relations between a multitude of diagnosis and laboratory values.
This article was published in the following journal.
Name: Artificial intelligence in medicine
As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the number of tools designed to analyse these data has dramatically increased. Navigating the vast sea of tools now avail...
The combination of textual data with visual features is known to enhance medical image search capabilities. However, the most advanced imaging archives today only index the studies' available meta-dat...
Used together, brief assessment tools, such as the PDQ9 and MDQ, have greater sensitivity and accuracy than clinician assessment alone.
Automated nucleic acid extraction from primary (raw) sputum continues to be a significant technical challenge for molecular diagnostics. In this work, we developed a prototype open-architecture, autom...
Textual representations play an important role in the field of natural language processing (NLP). The efficiency of NLP tasks, such as text comprehension and information extraction, can be significant...
the aim of this randomized controlled clinical study is to evaluate the efficacy of a new piezoelectric technique for wisdom teeth extraction without using manual tools versus the conventi...
This study is being conducted to compare the outcomes of two separate surgical techniques used in tooth extraction and ridge preservation. Ridge preservation is done to potentially minimiz...
The present retrospective study aims at assessing the clinical effects of a novel implant site development (Extraction site development - XSD) technique after tooth extraction compared wit...
This is a three-armed randomized controlled clinical trial aiming the estimation of dimensional alveolar bone changes after insertion of post-extraction implants through 3 different surgic...
Primary purpose : To develop a method to automatically extract and structure the information included in numerous medical records from breast cancer patients. Secondary purpose : ...
Use of various chemical separation and extraction methods, such as SOLID PHASE EXTRACTION; CHROMATOGRAPHY; and SUPERCRITICAL FLUID EXTRACTION; to prepare samples for analytical measurement of components.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
Facilities for collecting and organizing information. They may be specialized by subject field, type of source material, persons served, location, or type of services.
The selective extraction of deciduous teeth during the stage of mixed dentition in accordance with the shedding and eruption of the teeth. It is done over an extended period to allow autonomous adjustment to relieve crowding of the dental arches during the eruption of the lateral incisors, canines, and premolars, eventually involving the extraction of the first premolar teeth. (Dorland, 28th ed)
The art and science of designing buildings and structures. More generally, it is the design of the total built environment, including town planning, urban design, and landscape architecture.
Clinical Research Organization
Contract Research Organization (CRO) provide research services outsourced on a contract basis to the pharmaceutical, biotechnology, healthcare and medical device industries: biopharmaceutical development biologic assay development commercial...