Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation efficiency and pH responsive release.

08:00 EDT 3rd September 2018 | BioPortfolio

Summary of "Lotus leaf-inspired design of calcium alginate particles with superhigh drug encapsulation efficiency and pH responsive release."

Drug delivery systems with high drug encapsulation efficiency and controlled release are of great importance in biomedical fields. Herein, we report an ingenious approach inspired from the lotus leaf possessing the ability of strong repellency to water, which enables the rapid fabrication of drug-loaded calcium alginate (Ca-Alg) particles with high drug encapsulation efficiency and controlled drug delivery. The design is achieved by introducing aqueous droplets containing the mixture of dilute sodium alginate solution, dilute calcium chloride solution, and drug onto the superhydrophobic substrate. Due to water evaporation both the concentration of sodium alginate and calcium chloride within the droplets will gradually increase, and the ionic crosslinking reaction of sodium alginate with Ca is further occurred to form the drug-embedded Ca-Alg hydrogel particles. The results indicate that the controllable fabrication of Ca-Alg particles can be easily achieved on the superhydrophobic surface, and the swelling behavior can be tuned by the pH of the buffer solution. Importantly, the drug encapsulation efficiencies are measured to be over 88% and the drug exhibits obvious pH responsive release. Findings from this study are expected to contribute to the rational design of drug delivery systems with high drug encapsulation efficiency and controlled release for pharmaceutic science and tissue engineering.


Journal Details

This article was published in the following journal.

Name: Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Pages: 464-470


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Medical and Biotech [MESH] Definitions

A plant genus of the family NYMPHAEACEAE. The common name of lotus is also used for LOTUS and NELUMBO.

A plant genus of the family NELUMBONACEAE. The common name of lotus is also for LOTUS and NYMPHAEA.

A tribe of the PEA FAMILY. The genus Lotus, a member of this tribe and formerly known as Tetragonolobus, is unrelated to other plants with the common name of lotus (NELUMBO and NYMPHAEA).

A plant genus of the family FABACEAE. This genus was formerly known as Tetragonolobus. The common name of lotus is also used for NYMPHAEA and NELUMBO.

The third stomach of ruminants, situated on the right side of the abdomen at a higher level than the fourth stomach and between this latter and the second stomach, with both of which it communicates. From its inner surface project large numbers of leaves or folia, each of which possesses roughened surfaces. In the center of each folium is a band of muscle fibers which produces a rasping movement of the leaf when it contracts. One leaf rubs against those on either side of it, and large particles of food material are ground down between the rough surfaces, preparatory to further digestion in the succeeding parts of the alimentary canal. (Black's Veterinary Dictionary, 17th ed)

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