Advertisement

Topics

Nasal challenges in allergen immunotherapy trials.

08:00 EDT 7th September 2018 | BioPortfolio

Summary of "Nasal challenges in allergen immunotherapy trials."

The nasal allergen challenge (NAC) model can be a valuable diagnostic tool for allergic rhinitis. Alongside its clinical use, NACs can be used as primary and secondary endpoints in studies evaluating allergen immunotherapy (AIT) products for allergic rhinitis treatment. This review will discuss the technical aspects of the NAC model and provide a summary of recent studies using NACs to assess existing and new AIT treatments.

Affiliation

Journal Details

This article was published in the following journal.

Name: Current opinion in allergy and clinical immunology
ISSN: 1473-6322
Pages:

Links

DeepDyve research library

PubMed Articles [8182 Associated PubMed Articles listed on BioPortfolio]

Intralymphatic immunotherapy with two concomitant allergens, birch and grass - a RDBPC trial.

Intralymphatic immunotherapy (ILIT) with only three lymph node-injections was performed with a combination of grass and birch allergen, with maintained safety and reduced reactivity at nasal grass all...

Allergen immunotherapy as add-on to biologic agents.

In this review, we sought to outline many of the recent evidences about the available clinical trials in which biologic agents [i.e. omalizumab (OMA)] were associated as add-on to allergen-specific im...

Does evidence support the use of cat allergen immunotherapy?

Cat allergy can manifest as allergic rhinitis, conjunctivitis and/or asthma. With widespread cat ownership and exposure, cat allergy has emerged as a major cause of morbidity. Cat allergen immunothera...

Is Allergen Immunotherapy in Children Disease Modifying? A Review of the Evidence.

Although evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural hi...

Intralymphatic allergen-specific immunotherapy.

An emerging method for allergen-specific immunotherapy is intralymphatic placement, which only requires three injections with intervals of four weeks. In this review, we summarise available evidence o...

Clinical Trials [2028 Associated Clinical Trials listed on BioPortfolio]

Repeat Nasal Allergen Challenge

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response ...

Nasal Allergen Challenge - Reproducibility of Biomarkers and Effect of Topical Steroid Treatment

Subjects with allergic asthma developing the required nasal symptoms in response to nasal allergen titration during a screening period will be randomized 1:1 to one of 2 cohorts. All subje...

Evaluation of a Nasal Allergen Challenge Procedure Using Dust Mite Extract

The purpose of this study is to serve as a pilot safety study for nasal allergen challenges.

Repeat Dose Nasal Allergen Challenge

What happens in the nose during an allergic reaction? Are there changes that a new drug could treat? What is the best way to test new drugs?The response of the nose to being exposed to cat...

To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis

Allergic rhinitis is a common condition characterize by inflammation of the upper airways. Third generation antihistamines have been demonstrated effective in the treatment of this conditi...

Medical and Biotech [MESH] Definitions

A quantitative form of intradermal testing for the relative allergenicity of a substance. It is used to determine the amount of an allergen that will be tolerated in ALLERGEN IMMUNOTHERAPY.

Diagnostic measurement of the nose and its cavity through acoustic reflections. Used to measure nasal anatomical landmarks, nasal septal deviation, and nasal airway changes in response to allergen provocation tests (NASAL PROVOCATION TESTS).

Fluid obtained by irrigation or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.

A plant genus of the family POACEAE that contains the Poa p Ia allergen and allergen C KBGP.

The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Allergies
The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...

Immunology
Allergies Automimmune Disease Human Papillomavirus (HPV) Immunology Vaccine Immunology is the study of immunity and the defence mechanisms of the body. A greater understanding of immunology is needed to develop vaccines, understand ...


Searches Linking to this Article