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Generation of induced pluripotent stem cell line(ZZUi006-A)from a patient with myotonic dystrophy type 1.

08:00 EDT 22nd August 2018 | BioPortfolio

Summary of "Generation of induced pluripotent stem cell line(ZZUi006-A)from a patient with myotonic dystrophy type 1."

Myotonic dystrophy type 1 (DM1) is a dominantly inherited neurodegenerative disease caused by a CTG repeat expansion close to the DMPK gene. The fibroblasts from a patient with DM1 were successfully converted to induced pluripotent stem cells (iPSCs), designated ZZUi006-A, by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, L-MYC. The ZZUi006-A cell line may provide a robust platform for further study of DM1 pathogenesis as well as drug testing and gene therapy research.

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This article was published in the following journal.

Name: Stem cell research
ISSN: 1876-7753
Pages: 61-64

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Procedures used for the induction of CELLULAR REPROGRAMMING to change the terminal phenotype of a cell, such as the generation of INDUCED PLURIPOTENT STEM CELLS from differentiated adult cells by the forced expression of specific genes.

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