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The Food and Drug Administration (FDA) has recently included a black box warning on fibromyalgia like symptoms with fluoroquinolones (FQs) but no large epidemiologic study is to date available. We undertook a case-control study using a random sample of 9,053,240 subjects obtained from the PharMetrics Plus health claims database in the United States. Cases received at least two fibromyalgia diagnoses coded by a rheumatologist matched to a ten randomly selected controls. After identifying 5,148 cases of fibromyalgia and 51,480 controls, the adjusted rate ratio of fibromyalgia for use of any fluoroquinolones, amoxicillin, and azithromycin were 1.63 (95%
1.41-1.87), 1.64 (95%
1.46-1.85), and 1.68 (95% CI, 1.49-1.89) respectively. The adjusted RR for any use of FQ compared to any use of amoxicillin or azithromycin was 0.99 (95%
0.83-1.18) and azithromycin is 0.97 (95%
0.82-1.16) respectively. The risk of fibromyalgia with FQs is similar to that with amoxicillin and azithromycin.
This article was published in the following journal.
Name: British journal of clinical pharmacology
Several fluoroquinolone antibiotics have been associated with cardiac adverse effects, leading to the withdrawal of some of these agents from the market. Cardiac side effects such as QT prolongation a...
To develop and validate a risk assessment tool called Prescription Medication Non- Adherence Prediction Tool (Rx-NAPT) to predict medication non-adherence in patients with fibromyalgia.
Fluoroquinolone use might be associated with serious side effects. Urologists should always consider these potential risks associated with fluoroquinolones and participate in a shared-decision making ...
Our main goal was to investigate the potential accumulation of fluoroquinolones (FQs) in agricultural soils over extended periods of land use, predicting leaching and estimating risk quotients for soi...
Fibromyalgia is a common chronic pain disorder typically associated with headache disorders, particularly chronic daily headache. However, fibromyalgia is typically underdiagnosed and undertreated. Th...
The objective of the study is to evaluate the effectiveness of oral tetrahydrocannabinol in patients suffering from Fibromyalgia
The purpose of this study is to evaluate whether there is an increased risk of achilles tendon rupture (ATR), retinal detachment (RD) or aortic aneurysm and dissection (AAD) following expo...
The purpose of the study is to investigate safety, tolerability and efficacy of oral GW679769 up to 120 mg dose compared to placebo in patients with ACR(American College of Rheumatology)-d...
The present study is a new approach of examining tailored cognitive-behavioral interventions for fibromyalgia patients at risk. For this purpose, fibromyalgia patients are screened with re...
This is a 24-week, randomized, double-blind, placebo-controlled, trial to evaluate the safety, tolerability and efficacy of an orally administered growth hormone stimulating drug, (code n...
A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.
A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)
The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (FLUOROQUINOLONES) structurally related to NALIDIXIC ACID.
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...
In order to become availible to pateints, drugs need to undergo a number of phases of clinical trials to test their efficacy and safty and to then be authorised by the drug approval organistion in each respective country. This is the FDA in the USA and N...