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Oral Fluoroquinolones and Risk of Fibromyalgia.

08:00 EDT 14th September 2018 | BioPortfolio

Summary of "Oral Fluoroquinolones and Risk of Fibromyalgia."

The Food and Drug Administration (FDA) has recently included a black box warning on fibromyalgia like symptoms with fluoroquinolones (FQs) but no large epidemiologic study is to date available. We undertook a case-control study using a random sample of 9,053,240 subjects obtained from the PharMetrics Plus health claims database in the United States. Cases received at least two fibromyalgia diagnoses coded by a rheumatologist matched to a ten randomly selected controls. After identifying 5,148 cases of fibromyalgia and 51,480 controls, the adjusted rate ratio of fibromyalgia for use of any fluoroquinolones, amoxicillin, and azithromycin were 1.63 (95%
CI:
1.41-1.87), 1.64 (95%
CI:
1.46-1.85), and 1.68 (95% CI, 1.49-1.89) respectively. The adjusted RR for any use of FQ compared to any use of amoxicillin or azithromycin was 0.99 (95%
CI:
0.83-1.18) and azithromycin is 0.97 (95%
CI:
0.82-1.16) respectively. The risk of fibromyalgia with FQs is similar to that with amoxicillin and azithromycin.

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Journal Details

This article was published in the following journal.

Name: British journal of clinical pharmacology
ISSN: 1365-2125
Pages:

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