Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for Rheumatoid Arthritis.

08:00 EDT 14th September 2018 | BioPortfolio

Summary of "Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for Rheumatoid Arthritis."

Circular RNAs (circRNAs) are a new class of RNAs can be used as biomarkers in clinical blood samples. However, little is known about circRNAs' diagnostic values for rheumatoid arthritis (RA). In this study, the hsa_circ_0054189, hsa_circ_0008675, hsa_circ_0082689, hsa_circ_0082688, hsa_circ_0010932, hsa_circ_0002473 and hsa_circ_0044235 in peripheral blood were determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Hsa_circ_0044235, only one abnormal expression circRNAs in peripheral blood was selected as a targeted circRNA to explore the diagnostic value for RA. Our work demonstrated that, the hsa_circ_0044235 in peripheral blood was significantly decreased in RA patients. The hsa_circ_0044235 in peripheral blood from RA patients did not correlate with CRP, ESR, RF, ACPA or DAS28. ROC curve analysis suggested that the hsa_circ_0044235 in peripheral blood has significant value of RA diagnosis. And, the risk score based on hsa_circ_0044235 in peripheral blood also significantly distinguished the patients with RA from systemic lupus erythematosus (SLE). This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA. This article is protected by copyright. All rights reserved.


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This article was published in the following journal.

Name: Clinical and experimental immunology
ISSN: 1365-2249


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