Design of DNA-based Innovative Computing system of Digital Comparison.

08:00 EDT 14th September 2018 | BioPortfolio

Summary of "Design of DNA-based Innovative Computing system of Digital Comparison."

Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the basic unit in traditional electronic computers, but it is difficult to construct a system for achieving large-scale integration. Here, we construct, for the first time, a novel logic computing system of DCs that can compare whether two or more numbers are equal. Our approach is by taking advantage of facile preparation and unique properties of graphene oxide and DNA. The DC system reported in this work is developed by the DNA hybridization and effective combination of GO and single-stranded DNA, which is regarded as the reacting platform. On the basis of this platform and reaction principle, we have developed 2-inputs, 3-inputs, and 4-inputs DCs to realize the comparison of two or more binary numbers. We predict that such a state-of-the-art logic system enables its functionality with large-scale input signals, providing a new direction toward prototypical DNA-based logic operations and promoting the development of advanced logic computing.


Journal Details

This article was published in the following journal.

Name: Acta biomaterialia
ISSN: 1878-7568


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