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Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the basic unit in traditional electronic computers, but it is difficult to construct a system for achieving large-scale integration. Here, we construct, for the first time, a novel logic computing system of DCs that can compare whether two or more numbers are equal. Our approach is by taking advantage of facile preparation and unique properties of graphene oxide and DNA. The DC system reported in this work is developed by the DNA hybridization and effective combination of GO and single-stranded DNA, which is regarded as the reacting platform. On the basis of this platform and reaction principle, we have developed 2-inputs, 3-inputs, and 4-inputs DCs to realize the comparison of two or more binary numbers. We predict that such a state-of-the-art logic system enables its functionality with large-scale input signals, providing a new direction toward prototypical DNA-based logic operations and promoting the development of advanced logic computing.
This article was published in the following journal.
Name: Acta biomaterialia
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An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.
Comparison of various psychological, sociological, or cultural factors in order to assess the similarities or diversities occurring in two or more different cultures or societies.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
The process of converting analog data such as continually measured voltage to discrete, digital form.
A rapid, low-dose, digital imaging system using a small intraoral sensor instead of radiographic film, an intensifying screen, and a charge-coupled device. It presents the possibility of reduced patient exposure and minimal distortion, although resolution and latitude are inferior to standard dental radiography. A receiver is placed in the mouth, routing signals to a computer which images the signals on a screen or in print. It includes digitizing from x-ray film or any other detector. (From MEDLINE abstracts; personal communication from Dr. Charles Berthold, NIDR)
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