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The goal of this article is to examine the intersections of precision health and rare diseases. Specifically, we propose 3 lessons from the last decade of applying genomics to rare diseases: (1) precision can end one odyssey and start another; (2) precise interventions can exacerbate health disparities and create other ethical dilemmas; and (3) democratization of data will transform research and translation. By studying experiences of patients with rare diseases, researchers, clinicians, and policymakers can anticipate similar challenges in precision medicine and hopefully mitigate potential harms or injustices.
This article was published in the following journal.
Name: AMA journal of ethics
Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of an individual and, when present, his or her disease. It has a host of targets, including genes and their tra...
To date, the therapeutic paradigm for Alzheimer's disease (AD) focuses on a single intervention for all patients. However, a large literature in oncology supports the therapeutic benefits of a precisi...
Coronary heart disease (CHD) is a multifactorial disease with both genetic and environmental components. Smoking is the most important modifiable risk factor for CHD. Our aim was to test whether the i...
Genetics has given a real boost to personalized and precision medicine, providing data used either for precise diagnostics, prediction of the course of illness, or for selecting therapy and tailoring ...
The Precision Medicine Initiative defines precision medicine as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lif...
The incidence of rare diseases is extremely low, the disease is numerous, the symptoms are serious, and the detection technology is complicated. Countries have different definitions of rar...
The study aim of the DCM Precision Medicine Study is to test the hypothesis that DCM has a substantial genetic basis and to evaluate the effectiveness of a family communication interventio...
To evaluate the effectiveness of using clinical precision medicine to develop lifecourse interventions for Alzheimer's disease (AD) prevention and treatment. Anthropometrics, blood biomark...
The goal of delivering the right drug to the right cancer patient (precision medicine) requires a detailed understanding of how genomic alterations are linked to drug response. The purpose...
The investigators would like to create an online survey that queries current topics in precision medicine.
Clinical, therapeutic and diagnostic approaches to optimal disease management based on individual variations in a patient's genetic profile.
Metal devices for fastening together two or more parts of dental prostheses for stabilizing or retaining them by attachment to abutment teeth. For a precision attachment for a partial denture DENTURE PRECISION ATTACHMENT is available.
The detection of genetic variability (e.g., PHARMACOGENOMIC VARIANTS) relevant to PHARMACOGENETICS and PRECISION MEDICINE. The purpose of such genetic testing is to help determine the most effective treatment options and their optimum dosages with least potential risks for DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A precision device used for attaching a fixed or removable partial denture to the crown of an abutment tooth or a restoration. One type is the intracoronal attachment and the other type is the extracoronal attachment. It consists of a female portion within the coronal portion of the crown of an abutment and a fitted male portion attached to the denture proper. (Jablonski, Dictionary of Dentistry, 1992, p85; from Boucher's Clinical Dental Terminology, 4th ed, p264)