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DARK Classics in Chemical Neuroscience: Opium, a historical perspective.

08:00 EDT 24th September 2018 | BioPortfolio

Summary of "DARK Classics in Chemical Neuroscience: Opium, a historical perspective."

Opium is the latex from the opium poppy Papaver somniferum L. which man has utilized since ancient Mesopotamia all the way to modern times. Opium used to be surrounded in divine mystery or magic like abilities and was given to cure a wide verity of diseases until its analgesic, antitussive, and antidiarrheal properties were understood and the resulting alkaloids were isolated and their structure and properties unmasked. Opium went from being sold in any store front in the form of pills or tinctures with no prescription necessary for purchase, or smoked in an opium den down the street, to then bringing about consumer advocacy and the right to know what is in a medication. Legislation to limit the prescribing and selling of medications to doctors and pharmacists, as well as outlawing opium dens and smoking opium. This review will focus primarily on the uses of opium throughout history, the isolation of the principle alkaloids, and their structure elucidation.

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This article was published in the following journal.

Name: ACS chemical neuroscience
ISSN: 1948-7193
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The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.

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