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Phospholamban regulates nuclear Ca stores and inositol 1,4,5-trisphosphate mediated nuclear Ca cycling in cardiomyocytes.

08:00 EDT 24th September 2018 | BioPortfolio

Summary of "Phospholamban regulates nuclear Ca stores and inositol 1,4,5-trisphosphate mediated nuclear Ca cycling in cardiomyocytes."

Phospholamban (PLB) is the key regulator of the cardiac Ca pump (SERCA2a)-mediated sarcoplasmic reticulum Ca stores. We recently reported that PLB is highly concentrated in the nuclear envelope (NE) from where it can modulate perinuclear Ca handling of the cardiomyocytes (CMs). Since inositol 1,4,5-trisphosphate (IP) receptor (IPR) mediates nuclear Ca release, we examined whether the nuclear pool of PLB regulates IP-induced nuclear Ca handling.

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This article was published in the following journal.

Name: Journal of molecular and cellular cardiology
ISSN: 1095-8584
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Medical and Biotech [MESH] Definitions

Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.

Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.

Phosphoinositide phosphatases that catalyze the removal of the 5' phosphate from INOSITOL 1,4,5-TRISPHOSPHATE or myo-inositol 1,3,4,5-tetrakisphosphate, resulting in inositol 1,4-bisphosphate and phosphate. They have important functions in the metabolism of INOSITOL PHOSPHATES and inositol 1,4,5-trisphosphate signaling pathways such as CALCIUM SIGNALING.

A lattice of fibrils which covers the entire inner surface of the nuclear envelope and interlinks nuclear pores (NUCLEAR PORE).

A nuclear protein that regulates the expression of genes involved in a diverse array of processes related to metabolism and reproduction. The protein contains three nuclear receptor interaction domains and three repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 2.

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