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Esophageal cancer is one of the common cancers in China. More and more researches indicated that comprehensive treatment should be recommended for locally advanced esophageal cancer with resectable potential, especially the application of neoadjuvant chemoradiotherapy (CRT) was used to improve survival. However, the response to neoadjuvant chemoradiotherapy is various due to individual heterogeneity. Previous studies showed that pathological complete response (pCR) was considered as an important predictor of improved prognosis in esophageal cancer patients undergoing neoadjuvant CRT. Esophageal cancer patients with pCR had better prognosis than those without pCR. The watch and wait strategy may be a feasible option for surgically eligible rectal cancer patients with clinical complete response (cCR) after neoadjuvant chemoraidotherapy. Can the watch and wait strategy be used for reference to esophageal cancer? Whether patients with cCR following neoadjuvant CRT should undergo operation is analyzed in this article. According to present efficacy evaluation, cCR is inadequate to predict pCR. In addition, esophagectomy is favored for its curative effect and controllable complications. Therefore, we believe surgical resection, the chief component of multimodality treatment, should be recommended for all patients with locally advanced esophageal cancer.
This article was published in the following journal.
Name: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Given the potential morbidity of esophagectomy, patients may pursue other treatments. We sought to determine predictors and outcomes of esophageal cancer (EC) patients who refused esophagectomy.
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An internationally recognized set of published rules used for evaluation of cancer treatment that define when tumors found in cancer patients improve, worsen, or remain stable during treatment. These criteria are based specifically on the response of the tumor(s) to treatment, and not on the overall health status of the patient resulting from treatment.
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A scale that assesses the response to stimuli in patients with craniocerebral injuries. The parameters are eye opening, motor response, and verbal response.
A pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS.
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Polymerase Chain Reaction (PCR)
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