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Effect of celastrol on the progression of polycystic kidney disease in a Pkd1-deficient mouse model.

08:00 EDT 27th September 2018 | BioPortfolio

Summary of "Effect of celastrol on the progression of polycystic kidney disease in a Pkd1-deficient mouse model."

Celastrol, a naturally occurring pentacyclic triterpene, has attracted considerable interest because it exhibits potent anti-inflammatory and anti-tumor properties. However, the effects of celastrol in autosomal dominant polycystic kidney disease (ADPKD) remain uninvestigated.

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Name: Life sciences
ISSN: 1879-0631
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Medical and Biotech [MESH] Definitions

A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.

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