Changes in exercise capacity and serum BDNF following long-term sprint interval training in well-trained cyclists.

08:00 EDT 4th October 2018 | BioPortfolio

Summary of "Changes in exercise capacity and serum BDNF following long-term sprint interval training in well-trained cyclists."

The study determined the effects of sprint interval training on the acute and chronic changes of serum brain-derived neurotrophic factor (BDNF) and aerobic capacity. Twenty-six cyclists were divided into experimental (E) and control (C) group. Both groups executed 6-month exercise intervention involving high-intensity interval training (HIIT) and continuous endurance training (CET) with group E replacing HIIT and CET sessions with sprint interval training (SIT) executed twice a week. Two exercise tests were administered prior to the intervention and 2 and 6 months after study outset. Incremental exercise test (IXT) assessed aerobic capacity by measuring maximal oxygen uptake (VO2max) and work output, and sprint interval exercise test (SIXT; three sets of four 30-s all-out repetitions interspersed with 90 s of rest with sets separated by 25-40 min active recovery). Oxygen uptake, work output, BDNF and vascular endothelial growth factor A (VEGF-A) concentrations (baseline, 10 min after first set and 10 and 60 min after third SIXT set), were taken during the sprint interval exercise test. Significant decreases in BDNF relative to baseline values were observed 10 min after first set and 60 min after third set in group E at the 2- and 6-month assessments. Increases baseline VEGF-A after 2 and 6 months of training and increase VO2max after 2 months of training was also observed only in group E. The inclusion of SIT with HIIT and CET shows positive long-term effects including increased VO2max and baseline VEGF-A and reduction BDNF below baseline levels during and after SIXT.


Journal Details

This article was published in the following journal.

Name: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
ISSN: 1715-5320


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