PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs.
Summary of "PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs."
Multiple myeloma (MM) is a malignant plasma cell disease with a poor survival, characterized by the accumulation of myeloma cells (MMCs) within the bone marrow. Epigenetic modifications in MM are associated not only with cancer development and progression, but also with drug resistance.
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Journal Details
This article was published in the following journal.
Name: Clinical epigenetics
ISSN: 1868-7083
Pages: 121
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/30285865
- DOI: http://dx.doi.org/10.1186/s13148-018-0554-4
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