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Traceability of immunosuppressant's mass concentration results obtained using different commercial calibrators.

08:00 EDT 3rd October 2018 | BioPortfolio

Summary of "Traceability of immunosuppressant's mass concentration results obtained using different commercial calibrators."

Due to the high inter-variability in immunosuppressants pharmacokinetics, therapeutic drug monitoring of these drugs is essential in order to minimize the risk of rejection after organ transplantation. Thus, results facilitated to clinicians by clinical laboratories for these drugs should be as reliable as possible. The knowledge of metrological traceability and performing compatibility studies can allow ensuring reliability of these results, mainly, when laboratories introduce substantial changes in their measurement procedures, e.g., when they change the calibration materials. The aim of this study was to investigate, as an example, the traceability of the calibrator's assigned values from two manufacturers (Recipe and Chromsystems) and to perform compatibility studies for sirolimus and tacrolimus.

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This article was published in the following journal.

Name: Clinical biochemistry
ISSN: 1873-2933
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Medical and Biotech [MESH] Definitions

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

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An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.

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