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Traceability of immunosuppressant's mass concentration results obtained using different commercial calibrators.

08:00 EDT 3rd October 2018 | BioPortfolio

Summary of "Traceability of immunosuppressant's mass concentration results obtained using different commercial calibrators."

Due to the high inter-variability in immunosuppressants pharmacokinetics, therapeutic drug monitoring of these drugs is essential in order to minimize the risk of rejection after organ transplantation. Thus, results facilitated to clinicians by clinical laboratories for these drugs should be as reliable as possible. The knowledge of metrological traceability and performing compatibility studies can allow ensuring reliability of these results, mainly, when laboratories introduce substantial changes in their measurement procedures, e.g., when they change the calibration materials. The aim of this study was to investigate, as an example, the traceability of the calibrator's assigned values from two manufacturers (Recipe and Chromsystems) and to perform compatibility studies for sirolimus and tacrolimus.

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Name: Clinical biochemistry
ISSN: 1873-2933
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