Identification of novel Gata3 distal enhancers active in mouse embryonic lens.

08:00 EDT 8th October 2018 | BioPortfolio

Summary of "Identification of novel Gata3 distal enhancers active in mouse embryonic lens."

The tissue-specific transcriptional programs during normal development require tight control by distal cis-regulatory elements, such as enhancers, with specific DNA sequences recognized by transcription factors, coactivators and chromatin remodeling enzymes. Gata3 is a sequence-specific DNA binding transcription factor that regulates formation of multiple tissues and organs, including inner ear, lens, mammary gland, T-cells, urogenital system, and thyroid gland. In the eye, Gata3 has a highly restricted expression domain in the posterior part of the lens vesicle; however, the underlying regulatory mechanisms are unknown.


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This article was published in the following journal.

Name: Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177


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