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Targeting IL-1α in cancer cachexia: a narrative review.

08:00 EDT 8th October 2018 | BioPortfolio

Summary of "Targeting IL-1α in cancer cachexia: a narrative review."

Cachexia is defined as ongoing loss of skeletal muscle mass, with or without depletion of adipose tissue and is a common syndrome in cancer patients, affecting 50% of those diagnosed. Cachexia, which cannot be fully reversed and causes significant functional impairment is caused by various mechanisms such as an altered energy balance and disruption of homeostatic control by the central nervous system. This central nervous system deregulation involves hypothalamic pituitary adrenal (HPA) axis stimulation, which can be triggered by IL-1R1 engagement on neuronal processes and endothelium in the microvasculature of the hypothalamus. This review will explore current evidence regarding both the importance of IL-1α in the various components of cancer cachexia and its potential as a therapeutic target.

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This article was published in the following journal.

Name: Current opinion in supportive and palliative care
ISSN: 1751-4266
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