Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood.

08:00 EDT 10th October 2018 | BioPortfolio

Summary of "Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood."

Rapid detection of the anticoagulant effect of oral factor Xa (FXa) inhibitors may be essential in several emergency clinical situations. Specific assays quantifying the drugs are performed in plasma and require a turnaround time that is too long to be useful in emergency situations. Rotational thromboelastometry (ROTEM) is a whole blood coagulation assay of blood viscoelasticity and could be of interest for FXa inhibitor detection in emergency. However, conventional ROTEM reagents only detect high amounts of inhibitors.


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Name: European journal of anaesthesiology
ISSN: 1365-2346


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