Advertisement

Topics

Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood.

08:00 EDT 10th October 2018 | BioPortfolio

Summary of "Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood."

Rapid detection of the anticoagulant effect of oral factor Xa (FXa) inhibitors may be essential in several emergency clinical situations. Specific assays quantifying the drugs are performed in plasma and require a turnaround time that is too long to be useful in emergency situations. Rotational thromboelastometry (ROTEM) is a whole blood coagulation assay of blood viscoelasticity and could be of interest for FXa inhibitor detection in emergency. However, conventional ROTEM reagents only detect high amounts of inhibitors.

Affiliation

Journal Details

This article was published in the following journal.

Name: European journal of anaesthesiology
ISSN: 1365-2346
Pages:

Links

DeepDyve research library

PubMed Articles [18013 Associated PubMed Articles listed on BioPortfolio]

Safety and effectiveness of rivaroxaban and apixaban in patients with venous thromboembolism - a nationwide study.

To investigate the risk of all-cause mortality, recurrent VTE, and hospitalized bleeding in patients with VTE treated with either rivaroxaban or apixaban.

Direct oral anticoagulant agents: are they so safe?

The development of direct oral anticoagulant drugs (DOACs) directed towards a specific target has represented a great innovation in terms of both pharmacological research and clinical practice. At pre...

Real-world comparison of bleeding risks among non-valvular atrial fibrillation patients prescribed apixaban, dabigatran, or rivaroxaban.

Limited real-world data are available regarding the comparative safety of non-vitamin K antagonist oral anticoagulants (NOACs). The objective of this retrospective claims observational cohort study wa...

Bleeding rates of Veterans taking apixaban or rivaroxaban for atrial fibrillation or venous thromboembolism.

This study examined potential differences in bleeding between apixaban and rivaroxaban, the most commonly utilized direct oral anticoagulants at the Richard L. Roudebush VA Medical Center. Additionall...

A simple and fast HPLC-MS/MS method for simultaneous determination of direct oral anticoagulants apixaban, dabigatran, rivaroxaban in human plasma.

Direct Oral Anticoagulants (DOACs) available for the treatment and prevention of thromboembolic diseases include dabigatran, a direct thrombin (IIa) inhibitor, and apixaban, edoxaban and rivaroxaban, ...

Clinical Trials [6438 Associated Clinical Trials listed on BioPortfolio]

Which Anticoagulant, Apixaban or Rivaroxaban, Would be Better for Women That Have a Increased in Blood Loss During Menstruation

A large proportion of women with menstruating potential with newly diagnosed VTE or atrial fibrillation, treated with apixaban will have less menstrual blood loss than patients randomized ...

Comparison of Bleeding Risk Between Rivaroxaban and Apixaban

This pilot study compares rivaroxaban and apixaban, two of the new oral blood thinners for the treatment of blood clots. Half of the patients will receive apixaban and half will receive ri...

DAPHNE Study: Direct Anticoagulant PHarmacogeNEtic

New/direct oral anticoagulants (NOAC/DOAC), like apixaban and rivaroxaban, are an interesting alternative to unfractionated or low molecular weight heparin relayed by oral anti-vitamin K a...

Activates Charcoal for Patients Undergoing Invasive Procedure Delayed Due to Direct Oral Anticoagulants

This is a prospective, multicentric, randomized, open labeled superiority trial This study aims to evaluate the efficacy of oral activated charcoal for improving elimination of direct ora...

Apixaban Drug Utilization Study In Stroke Prevention In Atrial Fibrillation (Spaf)

Apixaban is a direct anticoagulant, which inhibits the factor Xa. Its clinical efficiency in prevention of stroke and systemic embolism in adult patients with NVAF (non/valvular atrial fib...

Medical and Biotech [MESH] Definitions

Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.

Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).

A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.

Ascertaining of deception through detection of emotional disturbance as manifested by changes in physiologic processes usually using a polygraph.

Environment un-modified by human activity. Areas in which natural processes operate without human interference.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Immunoassay - ELISA
Immunoassays are quick and accurate tests to detect specific molecules. Immunoassays rely on an antibody to bind to the specific structure of a molecule. Antibodies are proteins generated by animals in response to the invasion of a foreign molecule (anti...


Searches Linking to this Article