Surfaceome nanoscale organization and extracellular interaction networks.

08:00 EDT 8th October 2018 | BioPortfolio

Summary of "Surfaceome nanoscale organization and extracellular interaction networks."

The reductionist view of 'one target-one drug' has fueled the development of therapeutic agents to treat human disease. However, many compounds that have efficacy in vitro are inactive in complex in vivo systems. It has become clear that a molecular understanding of signaling networks is needed to address disease phenotypes in the human body. Protein signaling networks function at the molecular level through information transfer via protein-protein interactions. Cell surface exposed proteins, termed the surfaceome, are the gatekeepers between the intra- and extracellular signaling networks, translating extracellular cues into intracellular responses and vice versa. As 66% of drugs in the DrugBank target the surfaceome, these proteins are a key source for potential diagnostic and therapeutic agents. In this review article, we will discuss current knowledge about the spatial organization and molecular interactions of the surfaceome and provide a perspective on the technologies available for studying the extracellular surfaceome interaction network.


Journal Details

This article was published in the following journal.

Name: Current opinion in chemical biology
ISSN: 1879-0402
Pages: 26-33


DeepDyve research library

PubMed Articles [11854 Associated PubMed Articles listed on BioPortfolio]

Insect-flower interaction networks vary among endemic pollinator taxa over an elevation gradient.

Interaction networks are sensitive to elevation gradients through changes in local distribution of interacting partners. Here, we use plant-pollinator interaction network metrics to assess the effect ...

Random Matrix Analysis for Gene Interaction Networks in Cancer Cells.

Investigations of topological uniqueness of gene interaction networks in cancer cells are essential for understanding the disease. Although cancer is considered to originate from the topological alter...

Governing integrated care networks through collaborative inquiry.

The purpose of this paper is to develop a theory of governing in integrated care networks. Asking how and why the governance of these networks emerges and evolves over time, it responds to calls for m...

An integrative approach to develop computational pipeline for drug-target interaction network analysis.

Understanding the general principles governing the functioning of biological networks is a major challenge of the current era. Functionality of biological networks can be observed from drug and target...

Mapping the human brain's cortical-subcortical functional network organization.

Understanding complex systems such as the human brain requires characterization of the system's architecture across multiple levels of organization - from neurons, to local circuits, to brain regions,...

Clinical Trials [2023 Associated Clinical Trials listed on BioPortfolio]

Social Networks and Renal Education: Promoting Transplantation

There are significant and persistent disparities in access to kidney transplantation and as a result most patients with end stage renal disease receive hemodialysis (HD). HD is unique as i...

Family Networks (FaNs) for Children With Developmental Disorders and Delays

Over 6% of children in Pakistan suffer from a developmental disorder (intellectual disability or Autistic spectrum disorder) and most receive no intervention.In an earlier proof of concept...

Alkalinization by Urologists & Nephrologists

Metabolic acidosis recovers a wide range of diseases in which an oral alkalinization could be useful. This therapeutic intervention has been said to increase extracellular volume leading t...

Evaluation of the Organization of Continuity of Care for Home Hospice Patients by Four Parisian Health Networks

In Paris, France, home hospice care for terminally ill patients is organized by four "palliative care networks". These networks are responsible for information sharing and coordination of ...

Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss

1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance; 2. Comparing the expression levels o...

Medical and Biotech [MESH] Definitions

PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.

A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.

Region of interaction between the bone and PROSTHESES AND IMPLANTS which becomes bonded through cellular and extracellular interactions similar to OSSEOINTEGRATION.

The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.

Membrane limited structures derived from cell membranes and cytoplasmic material, and released into EXTRACELLULAR SPACE. They circulate through the EXTRACELLULAR FLUID and through the peripheral blood in the MICROVASCULATURE where cells, much larger, cannot, thereby affecting a variety of intercellular communication processes.

Quick Search


DeepDyve research library

Relevant Topics

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Article