Potential pro-oxidative effects of single dose of mephedrone in vital organs of mice.

08:00 EDT 29th May 2018 | BioPortfolio

Summary of "Potential pro-oxidative effects of single dose of mephedrone in vital organs of mice."

Mephedrone is a recreationally used synthetic cathinone, relatively new abusive substances with molecular structure similar to amphetamine. As there is still lack of scientific data regarding mechanisms of action as well as metabolism of mephedrone, especially in aspects other than neurotoxicity, addiction or behavioral changes, therefore we aimed, for the first time, to investigate potential pro-oxidative actions of a single dose of mephedrone in organs other than brain and its structures, i.e. in liver, kidneys, heart and spleen of Swiss mice.


Journal Details

This article was published in the following journal.

Name: Pharmacological reports : PR
ISSN: 1734-1140
Pages: 1097-1104


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A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

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The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

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Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.

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