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The effect of work-matched exercise intensity on β-cell function is unknown in people with prediabetes prior to clinical weight loss. We determined if short-term moderate continuous (CONT) versus high intensity interval (INT) exercise increased β-cell function. Thirty-one subjects (Age: 61.4±2.5 yr;
32.1±1.0 kg/m) with prediabetes (ADA criteria, 75g OGTT) were randomized to work-matched CONT (70% HRpeak) or INT (3 min 90% HRpeak and 3 min 50% HRpeak) exercise for 60min/d over 2-weeks. A 75g 2 hr OGTT was conducted after an overnight fast, and plasma glucose, insulin, C-peptide and FFA were determined for calculations of skeletal muscle (Oral Minimal Model; OMM), hepatic (HOMA-IR), and adipose (Adipose-IR) insulin sensitivity. β-cell function was defined from glucose-stimulated insulin secretion (GSIS, deconvolution modeling) and the disposition index (DI). GLP-1(active) and GIP were also measured during the OGTT, along with VO2peak and body composition. CONT and INT increased skeletal muscle, but not hepatic or adipose, derived DI ( P<0.05). Although both treatments tended to reduce fasting GLP-1(active) ( P=0.08), early phase GLP-1(active) increased post-CONT and INT training ( P<0.001). Interestingly, CONT exercise increased fasting GIP compared with decreases in INT ( P=0.02). Early and total phase skeletal muscle DI correlated with decreased total glucose area under the curve (r=-0.52, P=0.002 and r=-0.50, P=0.003, respectively). Independent of intensity, short-term training increased pancreatic function adjusted to skeletal muscle in relation to improved glucose tolerance in adults with prediabetes. Exercise also uniquely affected GIP and GLP-1(active). Further work is needed to elucidate the dose-dependent mechanism(s) by which exercise impacts glycemia.
This article was published in the following journal.
Name: Journal of applied physiology (Bethesda, Md. : 1985)
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