Impact of Short-Term Exercise Training Intensity on β-cell Function in Older Obese Adults with Prediabetes.

08:00 EDT 11th October 2018 | BioPortfolio

Summary of "Impact of Short-Term Exercise Training Intensity on β-cell Function in Older Obese Adults with Prediabetes."

The effect of work-matched exercise intensity on β-cell function is unknown in people with prediabetes prior to clinical weight loss. We determined if short-term moderate continuous (CONT) versus high intensity interval (INT) exercise increased β-cell function. Thirty-one subjects (Age: 61.4±2.5 yr;
32.1±1.0 kg/m) with prediabetes (ADA criteria, 75g OGTT) were randomized to work-matched CONT (70% HRpeak) or INT (3 min 90% HRpeak and 3 min 50% HRpeak) exercise for 60min/d over 2-weeks. A 75g 2 hr OGTT was conducted after an overnight fast, and plasma glucose, insulin, C-peptide and FFA were determined for calculations of skeletal muscle (Oral Minimal Model; OMM), hepatic (HOMA-IR), and adipose (Adipose-IR) insulin sensitivity. β-cell function was defined from glucose-stimulated insulin secretion (GSIS, deconvolution modeling) and the disposition index (DI). GLP-1(active) and GIP were also measured during the OGTT, along with VO2peak and body composition. CONT and INT increased skeletal muscle, but not hepatic or adipose, derived DI ( P<0.05). Although both treatments tended to reduce fasting GLP-1(active) ( P=0.08), early phase GLP-1(active) increased post-CONT and INT training ( P<0.001). Interestingly, CONT exercise increased fasting GIP compared with decreases in INT ( P=0.02). Early and total phase skeletal muscle DI correlated with decreased total glucose area under the curve (r=-0.52, P=0.002 and r=-0.50, P=0.003, respectively). Independent of intensity, short-term training increased pancreatic function adjusted to skeletal muscle in relation to improved glucose tolerance in adults with prediabetes. Exercise also uniquely affected GIP and GLP-1(active). Further work is needed to elucidate the dose-dependent mechanism(s) by which exercise impacts glycemia.


Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601


DeepDyve research library

PubMed Articles [42978 Associated PubMed Articles listed on BioPortfolio]

Short-Term High-Intensity Interval Training Is Superior to Moderate-Intensity Continuous Training in Improving Cardiac Autonomic Function in Children.

This study aimed to investigate the impact of 3 isocaloric exercise programs on cardiac autonomic nervous system (ANS) functioning in children.

Experimental Effects of Acute Exercise on Episodic Memory Function: Considerations for the Timing of Exercise.

Our previous work employing a between-subject randomized controlled trial design suggests that exercising prior to memory encoding is more advantageous in enhancing retrospective episodic memory funct...

Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity.

A key pathological component of obesity is chronic low-grade inflammation, which is propagated by infiltration of immune cells into tissues and overproduction of pro-inflammatory cytokines. Cytokines ...

Postprandial augmentation index is reduced in adults with prediabetes following continuous and interval exercise training.

Background People with prediabetes have elevated risk for cardiovascular disease (CVD) in part due to low insulin sensitivity mediated arterial stiffness. However, the effect of short-term exercise tr...

Evaluating the progressive cardiovascular health benefits of short-term high-intensity interval training.

High-intensity training is recognised as a time-efficient way of improving aerobic fitness. However, there is a lack of consensus regarding the temporal nature of adaptation response and which periphe...

Clinical Trials [24870 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Effects of Exercise Training and ARB in DM Patients

The aims of this clinical trial are to assess the impacts on vascular function tests and circulating biomarkers of a short-term (12-week) low-to-median intensity exercise training or ARBs ...

Effects of Acute High Intensity Exercise Training on Cardiac Function in Type II Diabetes

It is known from research that long-term exercise exposure in type 2 diabetes had positive effects. However, the effect of acute exercise in a patient group with already reduced cardiac fu...

High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

Aim: To assess whether there are different training effects on glucose concentration and cardiorespiratory parameters of different high-intensity training protocols in patients with type 2...

Investigation Into Optimal FES Training Characteristics After Sub-acute Spinal Cord Injury

The aim of this study is to investigate two different modalities of functional electrical stimulation (FES) leg exercise in sub-acute patients with spinal cord injury (SCI). The primary ou...

Personalized Moderate Intensity Exercise Training Combined With High Intensity Interval

The purpose of this study will be to determine if personalized moderate intensity exercise training combined with high intensity interval training is more effective at improving training r...

Medical and Biotech [MESH] Definitions

A cardiovascular exercise strategy with alternating short periods of intense anaerobic exercise with less-intense recovery periods.

Controlled physical activity, more strenuous than at rest, which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. The intensity of exercise is often graded, using criteria such as rate of work done, oxygen consumption, and heart rate.

A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

A type of strength-building exercise program that requires the body muscle to exert a force against some form of resistance, such as weight, stretch bands, water, or immovable objects. Resistance exercise is a combination of static and dynamic contractions involving shortening and lengthening of skeletal muscles.

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Quick Search


DeepDyve research library

Relevant Topic

Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...

Searches Linking to this Article