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Propofol pharmacokinetic and pharmacodynamic profile and its electroencephalographic interaction with remifentanil in children.

08:00 EDT 11th October 2018 | BioPortfolio

Summary of "Propofol pharmacokinetic and pharmacodynamic profile and its electroencephalographic interaction with remifentanil in children."

Propofol and remifentanil are commonly combined during total intravenous anesthesia. The impact of remifentanil in this relationship is poorly quantified in children. Derivation of an integrated pharmacokinetic and pharmacodynamic propofol model, containing remifentanil pharmacodynamic interaction information, enables propofol effect-site target-controlled infusion in children with a better prediction of its hypnotic effect when both drugs are combined.

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Name: Paediatric anaesthesia
ISSN: 1460-9592
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