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We introduce data assimilation as a computational method that uses machine learning to combine data with human knowledge in the form of mechanistic models in order to forecast future states, to impute missing data from the past by smoothing, and to infer measurable and unmeasurable quantities that represent clinically and scientifically important phenotypes. We demonstrate the advantages it affords in the context of type 2 diabetes by showing how data assimilation can be used to forecast future glucose values, to impute previously missing glucose values, and to infer type 2 diabetes phenotypes. At the heart of data assimilation is the mechanistic model, here an endocrine model. Such models can vary in complexity, contain testable hypotheses about important mechanics that govern the system (eg, nutrition's effect on glucose), and, as such, constrain the model space, allowing for accurate estimation using very little data.
This article was published in the following journal.
Name: Journal of the American Medical Informatics Association : JAMIA
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This trial is collaboration between Mayo Clinic, Second Opinion Health (Simon Bloch, email@example.com 408-981-3814) and Allergan. Mayo Clinic investigators are conducting the clini...
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A MACHINE LEARNING paradigm used to make predictions about future instances based on a given set of unlabeled paired input-output training (sample) data.
A MACHINE LEARNING paradigm used to make predictions about future instances based on a given set of labeled paired input-output training (sample) data.
A type of ARTIFICIAL INTELLIGENCE that enable COMPUTERS to independently initiate and execute LEARNING when exposed to new data.
SUPERVISED MACHINE LEARNING algorithm which learns to assign labels to objects from a set of training examples. Examples are learning to recognize fraudulent credit card activity by examining hundreds or thousands of fraudulent and non-fraudulent credit card activity, or learning to make disease diagnosis or prognosis based on automatic classification of microarray gene expression profiles drawn from hundreds or thousands of samples.
The visual display of data in a man-machine system. An example is when data is called from the computer and transmitted to a CATHODE RAY TUBE DISPLAY or LIQUID CRYSTAL display.
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