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Total Synthesis of Divergolides E and H.

08:00 EDT 12th October 2018 | BioPortfolio

Summary of "Total Synthesis of Divergolides E and H."

This manuscript describes the first total syntheses of divergolides E and H. The route employs a telescoped hetero Diels-Alder and oxidative carbon-hydrogen bond cleavage as an entry into the central bridged bicyclic acetal unit. Additional key steps of the highly convergent route include a desymmetrizing epoxidation, a chelation-controlled alkenylzinc addition, an amide formation between a hindered aniline and an acylating agent that is prone to ketene formation, and a challenging macrolactonization.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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