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Oxidation of Guanosine Monophosphate with O via a Ru-peroxo Complex in Water.

08:00 EDT 12th October 2018 | BioPortfolio

Summary of "Oxidation of Guanosine Monophosphate with O via a Ru-peroxo Complex in Water."

Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O and in water.

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This article was published in the following journal.

Name: Chemistry, an Asian journal
ISSN: 1861-471X
Pages:

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Medical and Biotech [MESH] Definitions

A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.

Guanosine 5'-monophosphate. A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.

Thiamine dihydrogen phosphate ester. The monophosphate ester of thiamine. Synonyms: monophosphothiamine; vitamin B1 monophosphate.

Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.

An enzyme that catalyzes the reversible oxidation of inosine 5'-phosphate (IMP) to guanosine 5'-phosphate (GMP) in the presence of AMMONIA and NADP+. This enzyme was formerly classified as EC 1.6.6.8.

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