Obinutuzumab, a new anti-CD20 antibody, and chlorambucil are active and effective in anti-MAG antibody polyneuropathy.
Summary of "Obinutuzumab, a new anti-CD20 antibody, and chlorambucil are active and effective in anti-MAG antibody polyneuropathy."
Rituximab, a chimeric anti-CD20 monoclonal antibody (mAb), has been used in polyneuropathy associated with anti-MAG antibody polyneuropathy with controversial results. Herein, we report on two patients with anti-MAG antibody neuropathy and concurrent chronic lymphocytic leukemia (CLL), who dramatically responded to obinutuzumab, a novel glycoengineered humanized anti-CD20 mAb.
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Journal Details
This article was published in the following journal.
Name: European journal of neurology
ISSN: 1468-1331
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/30315672
- DOI: http://dx.doi.org/10.1111/ene.13838
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