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Recent Progress in Fluorescence Signal Design for DNA-based Logic Circuits.

08:00 EDT 17th October 2018 | BioPortfolio

Summary of "Recent Progress in Fluorescence Signal Design for DNA-based Logic Circuits."

DNA-based logic circuits, encoding algorithm in DNA and processing information, are leading molecular computer forward to frontier, owing to DNA's advantages of stability, accessibility, manipulability, and especially inherent biological significance and potential medical application. In recent years, numerous logic functions, from arithmetic to nonarithmetic, have been realized based on DNA. However, DNA can hardly provide detectable signal by itself, so that the DNA-based circuits have to depend on extrinsic signal actuators. The signal strategy of carrying response out is becoming one of the design focuses in DNA-based logic circuit construction. Although works on sequence and structure design for DNA-based circuits have been well reviewed, the strategy on signal production lacks comprehensive summary. In this review, we focused on the latest designs of fluorescent output for DNA-based logic circuits. Several basic strategies were summarized and a few designs of developing multi-output systems were provided. In the end, some current difficulties and possible opportunities were also discussed.

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This article was published in the following journal.

Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
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