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Comparison of Congenital Malformations among Babies Born after Administration of Letrozole or Clomiphene Citrate for Infertility Treatment in a Korean Cohort.

08:00 EDT 16th October 2018 | BioPortfolio

Summary of "Comparison of Congenital Malformations among Babies Born after Administration of Letrozole or Clomiphene Citrate for Infertility Treatment in a Korean Cohort."

This retrospective study investigated and compared the incidence of congenital foetal anomalies after letrozole versus clomiphene citrate (CC) administration for infertility treatment. Data from 142 newborns were included: letrozole group, n = 83; CC group, n = 61. Congenital anomalies were found in 7.2% (6/83) patients in the letrozole group and 18.0% (11/61) patients in the CC group, with no significant between-group difference (p = .066). Major congenital anomaly rate was 2.4% (2/83) in the letrozole group and 3.3% (2/61) in the CC group, with no significant between-group difference (p > 0.999). There was no significant difference in major and minor congenital anomalies between the groups after excluding premature infants (birth at a gestational age of <37 weeks), low birth weight, and very low birth weight. The results of this study demonstrate the stability of letrozole compared to that of CC for infertility treatment in pregnant women.

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This article was published in the following journal.

Name: Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
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