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Endothelial Nitric Oxide Synthase (eNOS): Perspective and Recent Developments.

08:00 EDT 19th October 2018 | BioPortfolio

Summary of "Endothelial Nitric Oxide Synthase (eNOS): Perspective and Recent Developments."

Endothelial nitric oxide synthase (eNOS), and its product nitric oxide (NO), are vital components critical for the control of vasomotor function and cardiovascular homeostasis. In the present review, we will take a deep dive into eNOS enzymology, function and mechanisms regulating endothelial NO. The mechanisms regulating eNOS and NO synthesis discussed herein include alterations to transcriptional, post-translational modifications and protein-protein regulations. Moreover, we will discuss the phenotypes associated with various eNOS mutants and the consequences of a disrupted eNOS/NO cascade highlighting the importance of eNOS function and vascular homeostasis.

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This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381
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Medical and Biotech [MESH] Definitions

A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.

A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.

A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.

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