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Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer proliferation by partly silencing p21 expression.

08:00 EDT 21st October 2018 | BioPortfolio

Summary of "Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer proliferation by partly silencing p21 expression."

Colorectal cancer (CRC) is the third most common malignant in the world, and long noncoding RNA (lncRNA) has become a new gene. Here, we report a novel lncRNA MAPKAPK5-AS1 which acts as a critical oncogene in the CRC. In addition, we attempted to explore the functions of MAPKAPK5-AS1 on tumor progression in vitro and in vivo. qRT-PCR was performed to examine the expression of MAPKAPK5-AS1 in CRC tissues and cells. MAPKAPK5-AS1 expression was significantly up-regulated in 50 colorectal cancer tissues and increased expression of MAPKAPK5-AS1 was found to be associated with greater tumor size and advanced pathological stages in CRC patients. Knockdown of MAPKAPK5-AS1 significantly inhibited proliferation and caused apoptosis in CRC cells. Then,we found that p21 is a target of MAPKAPK5-AS1. In addition, we first demonstrated that MAPKAPK5-AS1 plays a carcinogenic role in colorectal cancer. MAPKAPK5-AS1 is a novel prognostic biomarker and a potential therapeutic candidate for CRC cancer. This article is protected by copyright. All rights reserved.

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Name: Cancer science
ISSN: 1349-7006
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