The use of quasi-experimental designs for vaccine evaluation.

08:00 EDT 22nd October 2018 | BioPortfolio

Summary of "The use of quasi-experimental designs for vaccine evaluation."

Randomised control trials are not always possible to evaluate interventions targeting infectious disease. This is frequently the case when evaluating the population level impact of vaccines or when evaluating interventions aiming to increase vaccine uptake. Under such circumstances an array of quasi-experimental designs is increasingly being used to evaluate the effect of vaccines on a wide range of morbidity and health service outcomes. These studies can provide valuable information on the impact of vaccination programmes and other related interventions in real world settings. Nevertheless, not all quasi-experimental designs are equal and it is important that authors and readers are aware of their relative strengths and potential sources of bias. In this paper we discuss what a quasi-experimental design is, when they might be used for vaccine evaluation, their strengths and limitations, and examples of their application.


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This article was published in the following journal.

Name: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591


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