Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseases.

08:00 EDT 20th October 2018 | BioPortfolio

Summary of "Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseases."

Ikaros, encoded by IKZF1 (Ikaros family zinc finger 1), is an important transcription factor in the control of lymphocyte specification and differentiation. Multiple functions of Ikaros have been exerted in almost all hematopoietic cell types, from stem cells to mature lymphoid and myeloid cells. Moreover, nonhematopoietic cells are also functional targets of Ikaros. Ikaros is essential for normal hematopoiesis, autoimmune and tumor suppression. Ikaros mutations were associated with lymphoblastic cells deficiency, autoimmunity and malignancies development, including hematological malignancies (leukemia) and solid tumors. This review focus on discuss the role of Ikaros in hematological malignancies, solid tumors and autoimmune diseases, and highlight the importance of Ikaros in cancer and immune diseases therapy.


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This article was published in the following journal.

Name: Gene
ISSN: 1879-0038


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Medical and Biotech [MESH] Definitions

A transcription factor that plays a role as a key regulator of HEMATOPOIESIS. Aberrant Ikaros expression has been associated with LYMPHOBLASTIC LEUKEMIA.


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