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Drug Addiction: Mechanisms of Nicotine Dependence Unmasked by Gene Editing.

08:00 EDT 22nd October 2018 | BioPortfolio

Summary of "Drug Addiction: Mechanisms of Nicotine Dependence Unmasked by Gene Editing."

New gene editing technologies are enabling exploration of previously intractable features of genetic risk for drug addiction. A recent study using this technology reveals new insights into how a mutation linked to tobacco dependence influences the addictive properties of nicotine.

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Journal Details

This article was published in the following journal.

Name: Current biology : CB
ISSN: 1879-0445
Pages: R1205-R1207

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Medical and Biotech [MESH] Definitions

Genetic engineering techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome.

A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

The dependence of tumor cells on a single oncogenic pathway or protein for their continued proliferation and survival.

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

The different gene transcripts generated from a single gene by RNA EDITING or ALTERNATIVE SPLICING of RNA PRECURSORS.

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