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Monitoring Src status after dasatinib treatment in HER2+ breast cancer with Zr-trastuzumab PET imaging.

08:00 EDT 25th October 2018 | BioPortfolio

Summary of "Monitoring Src status after dasatinib treatment in HER2+ breast cancer with Zr-trastuzumab PET imaging."

De novo or acquired resistance in breast cancer leads to treatment failures and disease progression. In human epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer, Src, a non-receptor tyrosine kinase, is identified as a major mechanism of trastuzumab resistance, with its activation stabilizing aberrant HER2 signaling, thus making it an attractive target for inhibition. Here, we explored the causal relationship between Src and HER2 by examining the potential of Zr-trastuzumab as a surrogate imaging marker of Src activity upon inhibition with dasatinib in HER2+ breast cancer.

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This article was published in the following journal.

Name: Breast cancer research : BCR
ISSN: 1465-542X
Pages: 130

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