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Measles and Rubella Seroprevalence in Mother-Infant Pairs in Rural Nepal and the United States: Pre- and Post-Elimination Populations.

08:00 EDT 1st November 2018 | BioPortfolio

Summary of "Measles and Rubella Seroprevalence in Mother-Infant Pairs in Rural Nepal and the United States: Pre- and Post-Elimination Populations."

We sought to compare seroprevalence of protective measles and rubella-specific antibody in mother-infant pairs across two populations: a pre-disease elimination Nepal population with recently introduced rubella vaccine and post-disease elimination U.S. population. Qualitative measles and rubella immunoglobulin G was assessed in maternal serum and cord blood from 258 pairs in Nepal, 2012-2013 and 49 pairs in Seattle, WA, 2014-2015. High rates of protective antibody were observed in both populations. Two hundred and forty-four (95%) pregnant women in Nepal had protective measles antibody versus 44 (92%) in Seattle ( = 0.42). Ninety-six percent of infants in Nepal ( = 246) and Seattle ( = 43) had protective measles antibody ( = 0.75). Ninety-four percentage of pregnant women in Nepal ( = 242) and Seattle ( = 45) had protective rubella antibody ( = 0.23). Two hundred and thirty-eight (93%) infants in Nepal had protective rubella antibody versus 44 (98%) in Seattle ( = 0.12). Continued surveillance will be necessary to ensure protective immunity, inform progress toward disease elimination in Nepal and avoid reemergence in the United States.

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Journal Details

This article was published in the following journal.

Name: The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Pages: 1342-1345

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Medical and Biotech [MESH] Definitions

A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.

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