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Performance of Tuberculin Skin Tests and Interferon-γ Release Assays in Children Younger Than 5 Years.

07:00 EST 1st December 2018 | BioPortfolio

Summary of "Performance of Tuberculin Skin Tests and Interferon-γ Release Assays in Children Younger Than 5 Years."

Available data to assess the optimal diagnostic approach in infants and preschool children at risk of tuberculosis (TB) are limited.

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This article was published in the following journal.

Name: The Pediatric infectious disease journal
ISSN: 1532-0987
Pages: 1235-1241

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Medical and Biotech [MESH] Definitions

One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.

A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.

The assay of INTERFERON-GAMMA released from lymphocytes after their exposure to a specific test antigen, to check for IMMUNOLOGIC MEMORY resulting from a previous exposure to the antigen. The amount of interferon-gamma released is usually assayed by an ENZYME-LINKED IMMUNOSORBENT ASSAY.

Protein factor(s) released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of LEUKOCYTES, especially polymorphonuclear cells, away from their site of release. Assays for these factors are used as tests for cellular immunity. Two of the common assays are the LEUKOCYTE MIGRATION CAPILLARY TUBE TECHNIQUE (LMCT) and the LEUKOCYTE MIGRATION AGAROSE TEST (LMAT).

Application of tests and examinations to identify visual defects or vision disorders occurring in specific populations, as in school children, the elderly, etc. It is differentiated from VISION TESTS, which are given to evaluate/measure individual visual performance not related to a specific population.

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