The cornerstone of integrating circulating tumor DNA into cancer management.

07:00 EST 9th November 2018 | BioPortfolio

Summary of "The cornerstone of integrating circulating tumor DNA into cancer management."

Recent circulating tumor DNA (ctDNA) research has demonstrated its potential as a non-invasive biomarker for cancer. However, the deployment of ctDNA assays in routine clinical practice remains challenging owing to variability in analytical approaches and the assessment of clinical significance. A well-developed, analytically valid ctDNA assay is a prerequisite for integrating ctDNA into cancer management, and an appropriate analytical technology is crucial for the development of a ctDNA assay. Other determinants including pre-analytical procedures, test validation, internal quality control (IQC), and continual proficiency testing (PT) are also important for the accuracy of ctDNA assays. In the present review, we will focus on the most widely used ctDNA detection technologies and the key quality management measures used to assure the accuracy of ctDNA assays. The aim of this review is to provide useful information for technology selection during ctDNA assay development and assure a reliable test result in clinical practice.


Journal Details

This article was published in the following journal.

Name: Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561


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Medical and Biotech [MESH] Definitions

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